Detalhe da pesquisa
1.
Sequence grammar underlying the unfolding and phase separation of globular proteins.
Mol Cell
; 82(17): 3193-3208.e8, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35853451
2.
Structural insights into the multifunctionality of rabies virus P3 protein.
Proc Natl Acad Sci U S A
; 120(14): e2217066120, 2023 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36989298
3.
Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate.
J Biol Chem
; 299(1): 102774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36481270
4.
A biosensor of protein foldedness identifies increased "holdase" activity of chaperones in the nucleus following increased cytosolic protein aggregation.
J Biol Chem
; 298(8): 102158, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35724963
5.
Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice.
Neurobiol Dis
; 176: 105933, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36436748
6.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Proc Natl Acad Sci U S A
; 117(5): 2422-2431, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964829
7.
Protein aggregation in cell biology: An aggregomics perspective of health and disease.
Semin Cell Dev Biol
; 99: 40-54, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29753879
8.
A Census of Hsp70-Mediated Proteome Solubility Changes upon Recovery from Heat Stress.
J Proteome Res
; 21(5): 1251-1261, 2022 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388693
9.
Flipping the switch: How cysteine oxidation directs tau amyloid conformations.
J Biol Chem
; 297(5): 101309, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34656563
10.
Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.
Mol Cell Proteomics
; 19(4): 640-654, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086375
11.
Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.
Mol Cell Neurosci
; 83: 103-112, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28743452
12.
When proteostasis goes bad: Protein aggregation in the cell.
IUBMB Life
; 69(2): 49-54, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28066979
13.
The 2021 FASEB Virtual Science Research Conference on Protein Aggregation: Function, Dysfunction, and Disease, June 23-25, 2021.
FASEB J
; 35(10): e21884, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463393
14.
Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.
Phys Chem Chem Phys
; 19(17): 10738-10747, 2017 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094373
15.
High-throughput quantitation of intracellular trafficking and organelle disruption by flow cytometry.
Traffic
; 15(5): 572-82, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24612275
16.
Walking the tightrope: proteostasis and neurodegenerative disease.
J Neurochem
; 137(4): 489-505, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26872075
17.
Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.
J Biol Chem
; 289(10): 6669-6680, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24425868
18.
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Nat Methods
; 9(5): 467-70, 2012 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22426490
19.
A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.
J Biol Chem
; 288(52): 37192-203, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196953
20.
The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9).
J Biol Chem
; 288(12): 8313-8320, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23355471